In this regard, the association between canonical Wnt/β-catenin signaling and IGF-1R signaling may contribute to the EMT process (395) In fact, in human colon cancer cells, IGF-1R promotes β-catenin translocation and stability by inhibiting GSK-3β, enhancing cell motility and facilitating colon cancer metastasis (396). This evidence concerns the gene GSK3B and malignant colon neoplasm.