IGF1R and diabetes mellitus: However, a recent study highlighted that inhibition of IGF-1R during a high-fat diet (HFD) can lead to a lipodystrophic phenotype characterized by a failure in WAT lipid storage (216) while mice lacking only IR or both IR and IGF-1R exhibit a lipodystrophic phenotype, characterized by severe diabetes, insulin resistance, and abnormal fat distribution in muscle and liver (217, 218).