KCNK3 and pulmonary arterial hypertension: Loss-of-function (LoF) mutations in TASK-1 cause an inherited form of hypertension (Pulmonary Arterial Hypertension; PAH)9, 10, whilst de novo gain-of-function (GoF) mutations have recently been shown to underlie a separate disorder termed Developmental Delay with Sleep Apnea (DDSA)11.