Hyperphosphorylation of the EGFR receptor has been previously reported in BRAF class 3–mutated NSCLC and colorectal cancer (CRC) cells, but not in malignant melanoma cells.6 Consistently, EGFR inhibition with erlotinib or cetuximab was effective in BRAF class 3–mutated NSCLC and CRC cell lines. This evidence concerns the gene EGFR and non-small cell lung carcinoma.