FCGR2B and systemic lupus erythematosus: This alteration in fungal content in the established lupus might be related to increased (1,3)-β-D-glucan (BG) (a major molecule component of the fungal cell wall), a major fungal cell wall component, associated with lupus-induced gut permeability defects, as previously reported in pristane and FcgRIIb-/- mice [11, 12].