Although Lamming et al. did not observe skeletal muscle glucose intolerance after 2 weeks of rapamycin administration in mice (2 mg /g per day for 2 weeks), muscle-specific deletion of Rictor in mice led to glucose intolerance and a reduction in HK2 expression in adults (3–5 months of age) [14, 19]. Here, HK2 is linked to Glucose intolerance.