To further explore the effect of TRPML1 on inflammatory infiltrate in lymphedema tissues, serum ELISA and tissue qPCR were performed in our lymphedema mouse model to detect inflammation-related indicators, including the release of the typical inflammatory factors IL-1β and IL-6, as well as the tissue fibrosis markers TGF-β1, collagen 1 (col-1), vimentin, and α-SMA [31, 32]. This evidence concerns the gene MCOLN1 and lymphedema.