Luo et al. reported high expression levels of STING1 (stimulator of interferon response cGAMP interactor 1) in patients with nonalcoholic steatohepatitis, MASLD, and in mice with diet-induced fatty liver [32]; this high expression of STING1 leads to reduced EVs secretion in normal human cells, as reported by Takahashi et al. Therefore, the reduction in EVs secretion in MASLD may reflect the pathology of the disease, that is, the characteristics of the cell source. This evidence concerns the gene STING1 and metabolic dysfunction-associated steatotic liver disease.