LMNA and Hutchinson-Gilford progeria syndrome: HGPS is most commonly caused by a point mutation in the LMNA gene which normally codes for lamin A and its splice variant lamin C. The LMNA mutation associated with HGPS leads to increased usage of a cryptic splice site which leads to the production of a truncated form of lamin A referred to as "progerin." Through mis-splicing, progerin is also expressed at low levels in healthy individuals and is believed to play a role in the normal aging process [29–32].