PTEN and melanoma: Here, we used a broader collection of established melanoma lines, again encompassing PTEN-deficient (WM266.4, WM793, and WM1158) and PTEN-proficient (A375 and A2058) cells, and sought to better understand any differential role of p110α and p110β through head-to-head comparison of antiproliferative and proapoptotic efficacy of AZD8835 and AZD8186.