However, deletion of either accelerated primary tumor development (median, BRAF PTEN, 51 days; BRAF P53, 79 days; BRAF, 407 days; Supplementary Fig. Fig. S2A–S2C), and decreased median overall survival (BRAF PTEN, 81 days; BRAF P53, 113 days; BRAF, 466 days; Fig. 1E). This evidence concerns the gene PTEN and neoplasm.