Melanocyte-specific expression of the BRAFV600E oncoprotein (Tyr-CreERT2BrafV600E/+–henceforth BRAF) resulted in robust development of naevi 2 to 6 weeks after induction (median onset, 24 days), with lowly penetrant melanoma observed in ∼40% (9/22) of mice within 1 year (median onset, 403 days; Supplementary Fig. S2A), in line with earlier studies carried out with these alleles (39). Here, BRAF is linked to melanoma.