Further research based on the findings is necessary to validate the efficacy of H3K27me3/EZH2 for predicting the malignancy of astrocytoma, IDH-mutant and to explore the association of H3K27me3/EZH2 with the molecular features of CDKN2A/B HD or the radiological characteristics. The gene discussed is EZH2; the disease is Huntington disease.