In terms of PFI, high expression of KLHL23 was identified as a risk factor for KIRP (P < 0.001), LIHC (P < 0.001), ACC (P = 0.001), SKCM (P = 0.003), and uveal melanoma (UVM, P = 0.013), while lower expression of KLHL23 was found to be a risk factor for LGG and GBM. The gene discussed is KLHL23; the disease is uveal melanoma.