Conversely, lower levels of KLHL23 expression were observed in five types of cancer when compared to normal tissue: bladder urothelial carcinoma (BLCA), ovarian cancer (OV), testicular germ cell tumors (TGCT), thyroid carcinoma (THCA), and uterine corpus endometrial carcinoma (UCEC) (Figure 1A). The gene discussed is KLHL23; the disease is thyroid gland carcinoma.