Conversely, lower levels of KLHL23 expression were observed in five types of cancer when compared to normal tissue: bladder urothelial carcinoma (BLCA), ovarian cancer (OV), testicular germ cell tumors (TGCT), thyroid carcinoma (THCA), and uterine corpus endometrial carcinoma (UCEC) (Figure 1A). This evidence concerns the gene KLHL23 and ovarian carcinoma.