To investigate whether SFPQ is aberrantly transported into the cytoplasm of brain cells under pathological conditions, we examined the colocalisation of SFPQ with glial fibrillary acidic protein (GFAP, an astrocyte‐specific marker) and microtubule‐associated protein 2 (MAP2, a neuron‐specific marker) in brain tissue slices from 6‐month‐old 5 × FAD mice, an Alzheimer's disease mouse model. Here, SFPQ is linked to early-onset autosomal dominant Alzheimer disease.