There was a negative correlation between serum IL-35 levels and Mayo score in ulcerative colitis (UC) patients.71Ebi3-/- and p35-/- mice were more sensitivity to colitis.29,30 Previous studies showed that CLA produced by locally probiotic bacteria in the gut that targets macrophage PPARγ to suppress colitis.72 Here, IL12A is linked to ulcerative colitis.