BAX and colorectal carcinoma: Apoptosis serves as a crucial process for preventing cancer progression, which is mediated by a balance between Bax (pro-apoptotic protein) and Bcl-2 (anti-apoptotic protein).29 Elevation of Bax triggers caspase activation, which induces the cleavage of poly (ADP-ribose) polymerase (PARP), ultimately leading to apoptosis.30 This study depicted that aconitine treatment markedly enhanced the apoptosis rate of CRC cells and increased the Bax/Bcl-2 ratio, as well as protein expression of cleaved-caspase3 and cleaved-PARP.