Ji et al. proposed that aconitine enhances pancreatic cell apoptosis and represses tumor cell growth by modulating the NF-κB pathway.20 Aconitine promotes reactive oxygen species and enhances tumor cell apoptosis, thereby alleviating the progression of hepatocellular carcinoma.21 Additionally, aconitine exhibits antitumor activity in ovarian cancer by elevating estrogen receptor β expression and mediating DNA damage, invasion, and apoptosis.22 However, whether aconitine also affects the aggressiveness of CRC is unclear. Here, NFKB1 is linked to neoplasm.