TRERNA1 and neoplasm: Besides, an RNA-seq analysis suggested that NRAS, as a potential target of TRERNA1, mediates certain aspects of hepatocellular carcinogenesis.41 Analysis of immune infiltration indicates a positive correlation between NRAS and the presence of CD68+ tumor-associated macrophages in HCC samples, with NRAS being linked to unfavorable HCC outcomes.42 These results suggested that these 5 genes may influence tumor progression by regulating LLPS and ferroptosis in HCC.