HSPB1, also known as HSP27, is a member of the small HSP family and has been shown to promote HCC metastasis via the Akt signaling pathway, potentially serving as a predictor for HCC patient outcomes.36 Additionally, HSPB1 has been identified as a negative regulator of ferroptosis, acting by reducing iron-mediated lipid ROS generation.37 Our analysis revealed that HSPB1 is also an LLPS-related DEG in HCC, underscoring its pivotal role in regulating both LLPS and ferroptosis within HCC. Here, HSP90B2P is linked to hepatocellular carcinoma.