ATF4 and hepatocellular carcinoma: Within the distinct environment of the LLPS droplet, pathological protein aggregation is notably enhanced, contributing to ferroptosis.14 Ferroptosis, a recently recognized cell death mode marked by iron accumulation and lipid peroxidation, has surfaced as a promising target for anticancer therapy.15,16 Studies have indicated that elevated ferroptosis levels enhance the radiosensitivity of HCC.17,18 Gao et al19 uncovered that YAP/TAZ and ATF4 mediate resistance to Sorafenib in HCC by inhibiting ferroptosis.