An 18-year-old female with grade 3 obesity presented with dry cough, dyspnea, fever, and myalgia of the lower limbs. Her CK level was 23,735, AST/ALT of 208/NA, LDH of 1,080 and creatinine was 6.01. She expired. The gene discussed is GPT; the disease is obesity due to melanocortin 4 receptor deficiency.