In this study, we found that the level of BCR-ABL P210 was significantly elevated in CML patients after contracting COVID-19, which was also demonstrated by detecting the difference in the BCR-ABL P210 level in mononuclear cells from CML patients after infection with a SARS-CoV-2 pseudovirus. The gene discussed is ABL1; the disease is chronic myelogenous leukemia, BCR-ABL1 positive.