Beyond instrumental examinations, several biomarkers have been proposed to identify SSc-ILD, such as the measurement of serum concentrations of alveolar epithelial proteins (i.e., surfactant proteins A and D, Krebs von den Lungen-6 antigen), chemokines and cytokines (CCL2, CCL18, CXCL10), metalloproteinases, acute phase cytokines (i.e., IL-6), but their application in daily practice is still limited (44). This evidence concerns the gene CXCL10 and interstitial lung disease.