In conclusion, TLR4+M2 positive monocytes (CD1c-CD80-TLR4+CD163+CD204+CD206+cells) and TLR4+M2 positive macrophages (CD68+CD80-CD86-TLR4+CD163+CD204+CD206+cells) represent a hybrid cell cluster that seems to be expressed on both peripheral blood, and for the first time, in the cellular infiltrate of lung samples from SSc-ILD patients. Here, CD80 is linked to systemic sclerosis.