TLR4 and interstitial lung disease: These patients were characterized by a median percentage of circulating M2 monocytes and hybrid TLR4+M2 monocytes lower than that observed in all others SSc-ILD patients (0.098 ± 0.05 vs 0.21 ± 0.2 and 0.016 ± 0.02 vs 0.05 ± 0.05, respectively).