mNOX-E36, a CCL2 inhibitor, can suppress the recruitment of pro-inflammatory MoMφs to the liver in murine models of CCL4-induced liver fibrosis and methionine-choline-deficient diet (MCD)-induced non-alcoholic steatohepatitis, therefore, the balance of macrophage subgroups can shift to a state that was dominated by reparative MoMφs, ultimately contributing to the fibrosis regression (87, 117, 135). This evidence concerns the gene CCL4 and Hepatic fibrosis.