KCs can modulate the occurrence and progression of liver fibrosis by regulating NOD-like receptor protein 3 (NLRP3) inflammasome, PRR, transforming growth factor-β (TGF-β) signaling pathway, and platelet-derived growth factor (PDGF) signaling pathway (61–64) (Figure 1). This evidence concerns the gene TGFB1 and Hepatic fibrosis.