Furthermore, genes associated with cognitive impairment in the ExN1, 3, 8, and InN1, 6 subpopulations, such as Ptpro, Lrp1b, Calb1, Ncam2, Kcnip4, and Synpr, were found to be up-regulated in the RE-CI group (Graphical abstract and Tables S6 and S7). The gene discussed is LRP1B; the disease is Cognitive impairment.