Fetuin-B levels and carotid intima media thickness (CIMT) were assessed in PCOS women. Circulating fetuin-B levels were significantly elevated in PCOS patients with IR. Increased fetuin-B levels is closely linked to hormonal-metabolic disturbance and increases cardiovascular risk in women with PCOS. CIMT, which is a good indicator of cardiovascular risk, was also found to be increased in PCOS subjects as compared to controls. The gene discussed is FETUB; the disease is polycystic ovary syndrome.