PTGS2 and neoplasm: The specific mechanism may involve complex regulation of multiple factors, including inflammatory response, cell proliferation, and differentiation.26 The degree of LC differentiation may reflect functional status of tumor cells, and highly differentiated tumor cells may have better function and tissue structure.27 Therefore, they may exhibit lower levels of COX-2, AQP1, and G17, as well as higher levels of PGI.24-27