The protein zonulin, an analogue of zonula occludens toxin, regulates intestinal TJ permeability through protein kinase C α-mediated actin polymerization.18 Increased intestinal permeability can allow toxins, microorganisms, and undigested food particles to enter the bloodstream, leading to inflammation and potentially triggering autoimmune diseases. The gene discussed is PROS1; the disease is autoimmune disease.