APP and cancer: The commonalities among these subtypes of secretases mainly include three points: (1) each subtype of secretase acts on APP as a substrate, but with different cleavage sites and products; (2) each subtype of secretase cleaves Notch receptors; (3) each subtype of secretase is closely related to the progression of cancer and AD, and secretase inhibitors play an important role in the treatment of cancer and AD.