The malignant cell lines have been chosen to illustrate HGSOC representability,11,12 including cells established from primary tumors (JHOS2, CAOV3, and OVCAR8) and metastatic tumors (Kuramochi, Ovsaho, COV318, COV362, OVCAR4, and OVCAR5) covering genomic heterogeneity such as TP53 and BRCA1/2 mutations, along with other genomic aberrations (Figure S1A). This evidence concerns the gene BRCA1 and metastatic neoplasm.