NOP2/Sun RNA methyltransferase 4 is an important regulator in RNA methylation.6,19 Reportedly, the level of RNA methylation is more elevated in HCC cells than in normal cells, and NSUN4 is regarded as the RNA methylation-related gene to predict the prognosis of HCC.19 Similarly, He et al20 reported that the overexpression of NSUN4 is tightly linked to the survival of HCC patients. This evidence concerns the gene NSUN4 and hepatocellular carcinoma.