For example, chronic inflammation can enhance myeloperoxidase (MPO) levels in the bloodstream, resulting in lipoprotein dysregulation; this can contribute to an increase in the occurrence of atherosclerosis and a reduction in the supply of nitric oxide, resulting in endothelial dysfunction, impaired vascular activity, and unstable atherosclerotic plaques, which further increase the risk of cardiovascular complications (20) (Figure 2). The gene discussed is MPO; the disease is endothelial dysfunction.