AKT1 and neoplasm: In contrast, some cardio-miRNAs, including miR-21, miR-19a, miR-92a/b, miR-25, miR-106b, miR-130b, miR-146b, and miR-210, contribute to tumor growth by directly targeting PTEN and counteracting its inhibitory effect on the PI3K/AKT pathway (164–184).