MPO and atherosclerosis: For example, chronic inflammation can enhance myeloperoxidase (MPO) levels in the bloodstream, resulting in lipoprotein dysregulation; this can contribute to an increase in the occurrence of atherosclerosis and a reduction in the supply of nitric oxide, resulting in endothelial dysfunction, impaired vascular activity, and unstable atherosclerotic plaques, which further increase the risk of cardiovascular complications (20) (Figure 2).