PAX8 and neoplasm: For poorly differentiated carcinomas with no clear gland formation, markers of squamous differentiation (p63, p40, CK5/6), neuroendocrine markers (synaptophysin, chromogranin), urothelial markers (GATA3, p63), and renal markers (PAX8) may be indicated based on the available clinical history and morphology of the tumor (39).