For poorly differentiated carcinomas with no clear gland formation, markers of squamous differentiation (p63, p40, CK5/6), neuroendocrine markers (synaptophysin, chromogranin), urothelial markers (GATA3, p63), and renal markers (PAX8) may be indicated based on the available clinical history and morphology of the tumor (39). This evidence concerns the gene SYP and neoplasm.