Haidar et al.explored this concept in a randomized crossover-controlled trial,revealing that diabetic adults achieved better glucose control andreduced hypoglycemia risk when using a closed-loop, dual-hormone pump.23 Since then it has been shown that repeated dosesof glucagon do not cause hepatic glycogen depletion, and glucose responsivenessto glucagon administration was similar regardless of prior glucagonadministration.24−26 These data suggest that smart delivery systems thatsense low glucose levels to release glucagon might be possible aspreventative treatments for hypoglycemia. Here, GCG is linked to Hypoglycemia.