Although insulin treatmentis extremely effective in lowering blood glucose from dangerous highs,episodes of moderate to severe hypoglycemia are common clinical complications.In such cases, where endogenous glucose counterregulation is inadequateto combat hyperinsulinemia and restore normoglycemia, glucagon isadministered as an emergency treatment to prevent clinical symptomsincluding malaise, cognitive impairment, seizure, and coma.10 This evidence concerns the gene GCG and Hypoglycemia.