Abnormal Tau from the AD brain has a visible gelshift when compared to normal Tau due to the presence of PTMs.55,56 We found that with the exception of GlcNAcN359 + pS305, which hasa slightly increased gel shift, the electrophoretic mobilities ofall Tau(291–391) constructs were similar (all proteoforms havean apparent molecular weight of ∼12 kDa). The gene discussed is MAPT; the disease is Alzheimer disease.