With regard to the relationship between the two genes and the immune environment of T2DM, ARHGEF9 expression was negatively correlated with the proportions of resting NK T cells, endothelial cells, aDCs, and mesangial cells, whereas SLPI expression was positively correlated with the proportions of epithelial cells, M1 macrophages, mast cells, and basophils (Figure 9E). Here, ARHGEF9 is linked to type 2 diabetes mellitus.