NLRP3 and stroke disorder: Mechanistically, high UA levels may induce inflammatory responses and oxidative stress by disrupting the integrity of the vascular endothelium and promoting the expression of nod-like receptor family pyrin domain-containing 3 (NLRP3) inflammasome vesicles; as well as decreasing nitric oxide bioavailability and disrupting vascular functions and other factors that contribute to the development of stroke (33, 34).