Having confirmed HFL1-hY-GFPneo was 46,XY with GFPneo-tagged ChrY (Figure 5C) and 201B7 was 46,XX (Figure 5D), we generated triple X syndrome model (47,XX,+X) iPSCs (Figure 5E) by transferring ChrX between hiPSCs (Table S5), and various Klinefelter's syndrome models from female iPSCs (Table S6) that were 47,XX,+Y (Figure 5F), 48,XX,+Y + Y (Figure 5G), and 47, XX,+Ypq- (Figure 5H) by transferring ChrY from male iPSCs to female iPSCs. Here, CFHR1 is linked to Klinefelter syndrome.