In the present study, we identified three de novo heterozygous missense variants in UNC13A (c.1892T>A/p.Met631Lys, c.1945T>C/p.Phe649Leu, and c.2441C>T/p.Pro814Leu in NM_001080421.3) in three unrelated probands with epileptic encephalopathies and intellectual disability (Fig. 1A; Fig. S1) based on exome sequencing of trios. The gene discussed is UNC13A; the disease is Epileptic encephalopathy.