Independent analysis of the small RNA transcriptomes of human colon cancer HCT116 WT and DROSHA-KO cells identified 114 miRNAs, 78 ysRNAs, 154 rsRNAs, and 279 tsRNAs to be appreciably expressed (≥ 20 transcripts per million (TPM)) in WT and/or KOs. Here, DROSHA is linked to colonic neoplasm.