Transcriptional upregulation of ALOXE3 by YAP promotes lipid peroxide accumulation and induces ferroptosis, making the YAP-ALOXE3 signaling pathway a potential biomarker for predicting ferroptosis-induced responses in hepatocellular carcinoma cells (Qin et al., 2021). This evidence concerns the gene ALOXE3 and hepatocellular carcinoma.