CD4 and esophageal squamous cell carcinoma: Compared to normal tissue, cancerous tissue in ESCC showed increased infiltration of memory B cells, activated memory CD4+ T cells, resting NK cells, M0 macrophages, M1 macrophages, resting dendritic cells, and activated dendritic cells and decreased infiltration of naive B cells, CD8+ T cells, follicular helper T cells, regulatory T cells, activated NK cells, monocytes, activated mast cells, and eosinophils (Figure 3C).