Growing evidence also suggests that FSH plays a significant role in the pathogenesis of various non-reproductive diseases that have been shown to be more prevalent during menopause, including osteoporosis, type 2 diabetes mellitus, obesity, cardiovascular disease, Alzheimer’s diseases and several cancers (Santoro et al., 2015; Taneja et al., 2019). This evidence concerns the gene BRD2 and obesity due to melanocortin 4 receptor deficiency.