In megalencephalic leukoencephalopathy with subcortical cysts (MLC), GPR37 preserves the stability of intercellular connections by negatively regulating the expression and function of glial MLC1 and glial cell adhesion molecule (GlialCAM), thereby ensuring normal cell adhesion and signal transmission (Pla-Casillanis et al., 2022). This evidence concerns the gene HEPACAM and leukoencephalopathy, megalencephalic.