IL6 and triple-A syndrome: Inhibition of IL6 signaling has been shown to limit progression of AAA in animal models,42 and is also associated with improved survival.43 In humans, IL6 is abundantly expressed in AAA tissue,44 and may even be a source of systemic IL6.45 Previous Mendelian randomization analyses have supported IL6 signaling in AAA risk,14,43 as well as potential effects of IL6 signaling on reducing progression on AAA, although this latter work was limited by low statistical power.