It has been reported that TRPM7 relies on calcium signaling to enhance O-GlcNAcylation levels of c-Myc and Cav-1 in cells, inhibiting their degradation and promoting the movement and metastasis of non-small cell lung cancer (NSCLC) cells [116] (Figure 2). The gene discussed is MYC; the disease is non-small cell lung carcinoma.