FUS and amyotrophic lateral sclerosis: Interestingly, a study on the FUS mutation-associated ALS (where FUS mutation-associated ALS patients do not develop TDP-43 proteinopathy) found that CK1δ/ε-mediated phosphorylation of FUS protein increased the solubility of FUS in vitro and overexpression of CK1δ significantly rescued degeneration in a transgenic fly model [25].