HCST and lung adenocarcinoma: Among the four types of c-Met CAR-NK-92 cells transduced with CAR structures of the same NKG2D and CD3ζ as transmembrane and activating domains but with four costimulatory domain combinations (4-1BB, 2B4, 4-1BB-2B4, 2B4-DAP10), c-Met CAR-NK-92 cells with the intracellular domain of 2B4-DAP10-CD3ζ exhibited superior cytotoxicity in vitro in a concentration-dependent manner for high c-Met expression LUAD (lung adenocarcinoma) cell lines and inhibited non-small cell lung cancer (NSCLC) xenograft growth in vivo [227].