Given that HIF1 drives angiogenesis in ccRCC tumours [46], we were unsurprised to find HIF1 TFs target genes in MDE as this cluster was enriched for angiogenesis related GO terms (Fig. 2a–b, Additional file 1: Fig. S2a, Table S3). The gene discussed is HIF1A; the disease is nonpapillary renal cell carcinoma.