However, given the limited literature describing the effects of AD on the CP tissue and associated vasculature, as well as the fact that several functional parameters contribute to the BCSFB-ASL measurements, we cannot exclude the possibility of other factors increasing the measured rate of water delivery across the BCSFB in 3xTg mice, such as increased activity of transporters involved in water movement, as well as increased perfusion to the BCSFB itself. The gene discussed is CP; the disease is Alzheimer disease.