DACH2 and Alzheimer disease: The rs1326297223 index variant is located in an intron of DACH2. It was identified in the r-XCI meta-analysis excluding AD-proxy cases (MAF = 2.10 × 10−3, OR = 2.281 [1.629–3.192], P = 1.56 × 10−6, Table 1 and Supplementary Fig. S11), and its odds-ratio was consistent across studies and sensitivity analyses (Supplementary Table S8).