All the suggestive loci contain XLID putative causal genes, except DACH2. However, we did not detect an enrichment of the AD association signals in the XLID genes in any of the analyses (P = 0.37, 0.33 and 0.53 in r-XCI, e-XCI and s-XCI approaches, respectively). The gene discussed is DACH2; the disease is Alzheimer disease.