Three rare variants, all in high LD (r2 > 0.8), were associated at the X-chromosome-wide significance threshold with AD-risk in the TMEM187-G6PD/IKBKG (Transmembrane Protein 187, Glucose-6-Phosphate Dehydrogenase and Inhibitor Of Nuclear Factor Kappa B Kinase Regulatory Subunit Gamma) locus (Supplementary Table S10). This evidence concerns the gene TMEM187 and Alzheimer disease.