Focusing on CRC patients with high tumor purity from the TCGA database, we found a resistant oncogenic signature of immune evasion (including REG4, CTSE, MUC1, TFF2, LCN2) that inversely correlated with cytotoxicity and immune infiltration deconvolution scores (T- and NK-cells) (Fig. 4F). This evidence concerns the gene REG4 and neoplasm.