In existing reports, lncRNA FTO-IT1, METTL3, and HOXD-AS2 were all stated to be upregulated in HCC and associated with a poor prognosis of patients, which is similar to our results.22-24 To better understand the characteristics and mechanism of low LINC00449 expression, the impact of dysregulated LINC00449 on the biological function of HCC cells was clarified. The gene discussed is HOXD-AS2; the disease is hepatocellular carcinoma.