Additionally, miR-329-3p was indicated to target KDM1A and inhibit the immunosuppression of HCC cells.25 USP22 was also a targeting factor of miR-329-3p, which attenuated the activity of HCC cells by regulating the USP22-Wnt/β-Catenin pathway.26 Furthermore, the recovery assay revealed that the miR-329-3p inhibitor restored the suppressive effects of silencing LINC00449 on cell proliferation, apoptosis, migration, and invasion. This evidence concerns the gene USP22 and hepatocellular carcinoma.