[15] Moreover, recent studies have demonstrated that intratumoral Cu levels are essential in regulating PD‐L1 expression,[16] and cuproptosis might correlate with tumor immune evasion.[17] Accordingly, seeking available strategies to combine glucose starvation and cuproptosis might be a reinforcement for lung cancer αPD‐L1 therapy. The gene discussed is CD274; the disease is lung carcinoma.