HAO1 and cancer: Notably, as an emerging cancer therapeutic approach, cancer metabolism‐targeted therapy has drawn great interest.[5] Abnormal metabolism with excessive nutrition, especially glucose addiction, is one of the hallmarks of cancer tissues, offering an excellent opportunity to restrain cancerous cells by limiting glucose consumption.[6] Glucose oxidase (GOx), a natural enzyme catalyst, can effectively convert glucose into gluconic acid and hydrogen peroxide (H2O2),[7] thus being an excellent inducer for tumor starvation therapy and a potential regulator for glucose metabolism.