CD274 and lung cancer: In this study, we noticed that low glucose could significantly upregulate PD‐L1 levels on LLC lung cancer cells and activate the glycolysis pathway (Figure 1A–D), similar to previous findings.[26] Meanwhile, according to our RNA‐seq findings, low glucose treatment may influence intracellular copper balance (Figure 1D–F), inspiring us to further intervene intracellular copper content.