CD274 and cancer: Studies have shown that limiting glucose could induce cell oxidative stress by decreasing NADPH production.[27] Accumulated intracellular copper can also cause oxidative stress and lead to cuproptosis, which has been systemically verified as a potent cancer therapy.[14b] By combining low glucose treatment and cuproptosis, the intracellular ROS generation and PD‐L1 levels in LLC cells could be significantly enhanced simultaneously (Figure 1G–J), which would synergistically sensitize αPD‐L1 immunotherapy.