The results indicate that age, race, education level, moderate leisure, high work intensity, income-to-poverty ratio, albumin (ALB g/L), alanine aminotransferase (ALT U/L), blood urea nitrogen (BUN mmol/L), total cholesterol (TC mmol/L), creatinine (Cr μmol/L), lactate dehydrogenase (LDH U/L), total protein (TP g/L), potassium (K mmol/L), osmolality (Osm mmol/kg), globulin (GLB g/L), and glycohemoglobin (GHb %) were among the 19 potential characteristics that were significantly different (p < 0.05) between the two groups of patients with diabetes with and without periodontitis. This evidence concerns the gene ALB and periodontitis.