In contrast, knockdown of miR‐27b‐3p or overexpression of PD‐L1 in CRC cells partially impeded this effect, suggesting that circ_0089761/miR‐27b‐3p/PD‐L1 axis in CRC cells was involved in CD8 + T cell growth and death. This evidence concerns the gene CD274 and colorectal carcinoma.