Here, we found that circ_0089761 competed with the key immunomodulatory gene PD‐L1 for miR‐27b‐3p and deregulated the inhibitory effect of miR‐27b‐3p on PD‐L1, which led to an increase in PD‐L1 expression and enhanced metastatic ability of CRC cells. The gene discussed is CD274; the disease is colorectal carcinoma.