Furthermore, ablation of circ_0089761 in CRC cells also increased the secretion of IFN‐γ, TNF‐α, perforin, and granzyme‐B in CD8 + T cells (Figure 7c–f), whereas the increase in cytokine secretion induced by si‐circ_0089761 was partially suppressed after miR‐27b‐3p depletion or PD‐L1 overexpression. This evidence concerns the gene CD274 and colorectal carcinoma.